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Literature summary for 3.4.21.6 extracted from

  • Nishida, H.; Miyazaki, Y.; Kitamura, Y.; Ohashi, M.; Matsusue, T.; Okamoto, A.; Hosaka, Y.; Ohnishi, S.; Mochizuki, H.
    Synthesis and evaluation of 1-arylsulfonyl-3-piperazinone derivatives as factor Xa inhibitor (2001), Chem. Pharm. Bull., 49, 1237-1244.
    View publication on PubMed
Search for more literature for 3.4.21.6

Application

Application Comment Organism
pharmacology enzyme is a major target for new therapeutics in prevention of blood coagulation Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
4-[(6-chloro-2-naphthalenyl)sulfonyl]-1-[[1-(4-pyridinyl)-4-piperidinyl]-methyl]piperazinone i.e. M55113, strong inhibitor, highly selective for factor Xa over trypsin and thrombin Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
prothrombin + H2O Homo sapiens key enzyme in coagulation cascade responsible for the generation of thrombin by limited proteolysis of its zymogen prothrombin thrombin + ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Reaction

Reaction Comment Organism Reaction ID
selective cleavage of Arg-/-Thr and then Arg-/-Ile bonds in prothrombin to form thrombin scutelarin has similar specificity Homo sapiens
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
prothrombin + H2O
-
 Homo sapiens thrombin + ?
-
 ?
prothrombin + H2O key enzyme in coagulation cascade responsible for the generation of thrombin by limited proteolysis of its zymogen prothrombin Homo sapiens thrombin + ?
-
 ?

Synonyms

Synonyms Comment Organism
factor Xa
-
 Homo sapiens
FXa
-
 Homo sapiens
More the enzyme belongs to the peptidase family S1, i.e. trypsin family Homo sapiens