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Literature summary for 3.4.21.53 extracted from
- Distinct quaternary structures of the AAA+ Lon protease control substrate degradation (2013), Proc. Natl. Acad. Sci. USA, 110, E2002-E2008.
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 525000 | - |
hexamer, gel filtration and sedimentation velocity analytical ultracentrifugation | Escherichia coli |
| 930000 | - |
dodecamer, gel filtration and sedimentation velocity analytical ultracentrifugation | Escherichia coli |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| additional information | compared with hexamers, enzyme dodecamers are much less active in degrading large substrates but equally active in degrading small substrates, whcih represents a a unique gating mechanism that allows the repertoire of enzyme substrates to be tuned by its assembly state | Escherichia coli | ? | - |
? |  |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| dodecamer | hexamers of Escherichia coli Lon also interact to form a dodecamer at physiological protein concentrations, the dodecamer shows a prolate structure with the protease chambers at the distal ends and a matrix of N domains forming an equatorial hexamer-hexamer interface, with portals of about 45 A providing access to the enzyme lumen | Escherichia coli |
| homohexamer | - |
Escherichia coli |
| More | compared with hexamers, enzyme dodecamers are much less active in degrading large substrates but equally active in degrading small substrates | Escherichia coli |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lon | - |
Escherichia coli |
| lon protease | - |
Escherichia coli |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | Lon is an ATPase associated with cellular activities protease that controls cell division in response to stress and also degrades misfolded and damaged proteins | Escherichia coli |
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