Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
525000 | - |
hexamer, gel filtration and sedimentation velocity analytical ultracentrifugation | Escherichia coli |
930000 | - |
dodecamer, gel filtration and sedimentation velocity analytical ultracentrifugation | Escherichia coli |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Escherichia coli | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | compared with hexamers, enzyme dodecamers are much less active in degrading large substrates but equally active in degrading small substrates, whcih represents a a unique gating mechanism that allows the repertoire of enzyme substrates to be tuned by its assembly state | Escherichia coli | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
dodecamer | hexamers of Escherichia coli Lon also interact to form a dodecamer at physiological protein concentrations, the dodecamer shows a prolate structure with the protease chambers at the distal ends and a matrix of N domains forming an equatorial hexamer-hexamer interface, with portals of about 45 A providing access to the enzyme lumen | Escherichia coli |
homohexamer | - |
Escherichia coli |
More | compared with hexamers, enzyme dodecamers are much less active in degrading large substrates but equally active in degrading small substrates | Escherichia coli |
Synonyms | Comment | Organism |
---|---|---|
lon | - |
Escherichia coli |
lon protease | - |
Escherichia coli |
General Information | Comment | Organism |
---|---|---|
physiological function | Lon is an ATPase associated with cellular activities protease that controls cell division in response to stress and also degrades misfolded and damaged proteins | Escherichia coli |