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Literature summary for 3.4.21.53 extracted from
- A role for Lon protease in the control of the acid resistance genes of Escherichia coli (2008), Mol. Microbiol., 69, 534-547.
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | in gene disruption mutant lon::Tn10 members of the RcsA regulon and many genes of the sigmaS-dependent general stress response are upregulated. The lon mutation does not affect sigmaS levels nor sigmaS activity in general. Lon-affected genes also include the major acid resistance genes | Escherichia coli |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acid resistance regulator GdE protein + H2O | Escherichia coli | degradation of GadE protein by Lon rapidly terminates the acid resistance response upon shift back to neutral pH and avoids overexpression of acid resistance genes in stationary phases | ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Escherichia coli | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| acid resistance regulator GdE protein + H2O | degradation of GadE protein by Lon rapidly terminates the acid resistance response upon shift back to neutral pH and avoids overexpression of acid resistance genes in stationary phases | Escherichia coli | ? | - |
? | |
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