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Literature summary for 3.4.21.53 extracted from

  • Takaya, A.; Tabuchi, F.; Tsuchiya, H.; Isogai, E.; Yamamoto, T.
    Negative regulation of quorum-sensing systems in Pseudomonas aeruginosa by ATP-dependent Lon protease (2008), J. Bacteriol., 190, 4181-4188.
    View publication on PubMedView publication on EuropePMC
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Cloned(Commentary)

Cloned (Comment) Organism
-
 Pseudomonas aeruginosa
gene lon, expression analysis in wild-type and mutant strains by quantitative, real-time reverse transcription PCR, overview Pseudomonas aeruginosa

Protein Variants

Protein Variants Comment Organism
additional information construction of quorum-sensing signaling system mutant strains, gene lon disrupted cells of mutant strain, CS9008 overproduce pyocyanin, the biosynthesis of which depends on the RhlR/RhlI system, and show increased levels of a transcriptional regulator RhlR, phenotype, overview Pseudomonas aeruginosa
additional information cells with Lon protease gene disruption overproduce pyocyanin and show increased levels of transcriptional regulator RhlR and increased expression of LasR/LasI. Regulation of RhlR/RhlI by Lon is independent of LasR/LasI Pseudomonas aeruginosa

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
89000
-
 x * 89000, Lon, SDS-PAGE Pseudomonas aeruginosa

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
LasI + H2O Pseudomonas aeruginosa Lon is involved in the regulation of quorum-sensing signaling systems in Pseudomonas aeruginosa, the opportunistic human pathogen. The enzyme is part of the acyl-homoserine lactone-mediated QS system LasR/LasI, but LasR/LasI regulation is independent of the RhlR/RhlI system by Lon. QS systems are organized hierarchically: the RhlR/RhlI system is subordinate to LasR/LasI, Lon represses the expression of LasR/LasI by degrading LasI, an HSL synthase, leading to negative regulation of the RhlR/RhlI system, overview ?
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 ?
additional information Pseudomonas aeruginosa protease Lon represses the expression of LasR/LasI by degrading HSL synthase LasI, leading to negative regulation of the RhlR/RhlI system. RhlI/RhlR is also regulated by Lon independently of LasI/LasR ?
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 ?

Organism

Organism UniProt Comment Textmining
Pseudomonas aeruginosa
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-
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Pseudomonas aeruginosa Q9I2T9 gene lon
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
LasI + H2O Lon is involved in the regulation of quorum-sensing signaling systems in Pseudomonas aeruginosa, the opportunistic human pathogen. The enzyme is part of the acyl-homoserine lactone-mediated QS system LasR/LasI, but LasR/LasI regulation is independent of the RhlR/RhlI system by Lon. QS systems are organized hierarchically: the RhlR/RhlI system is subordinate to LasR/LasI, Lon represses the expression of LasR/LasI by degrading LasI, an HSL synthase, leading to negative regulation of the RhlR/RhlI system, overview Pseudomonas aeruginosa ?
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 ?
LasI + H2O hydrolytic degradation Pseudomonas aeruginosa ?
-
 ?
additional information protease Lon represses the expression of LasR/LasI by degrading HSL synthase LasI, leading to negative regulation of the RhlR/RhlI system. RhlI/RhlR is also regulated by Lon independently of LasI/LasR Pseudomonas aeruginosa ?
-
 ?

Subunits

Subunits Comment Organism
? x * 89000, Lon, SDS-PAGE Pseudomonas aeruginosa

Synonyms

Synonyms Comment Organism
ATP-dependent lon protease
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 Pseudomonas aeruginosa
lon
-
 Pseudomonas aeruginosa

Cofactor

Cofactor Comment Organism Structure
ATP dependent on Pseudomonas aeruginosa