Application | Comment | Organism |
---|---|---|
additional information | lon may be an important defense mechanism to protect mitochondria of steroidogenic cells against oxidative damage induced by steroid hydroxylation and to maintain the level of postfunctional steroidogenic acute regulatory protein compatible with mitochondrial homeostasis | Homo sapiens |
Cloned (Comment) | Organism |
---|---|
into the NdeI and BamHI sites of proEX, lon (proEX-Lon-His) expressed in Escherichia coli. Plasmid lon O/Ex expressed in COS cells | Homo sapiens |
Protein Variants | Comment | Organism |
---|---|---|
additional information | lon- mutant, steroidogenic acute regulatory protein turnover is blocked | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
clasto-lactacystin beta-lactone | blocks lon-mediated degradation of steroidogenic acute regulatory protein or FITC casein | Homo sapiens | |
MG132 | blocks lon-mediated degradation of steroidogenic acute regulatory protein or FITC casein | Homo sapiens | |
additional information | not inhibited by epoxomicin | Homo sapiens | |
RNAi | knockdown of lon | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Purification (Comment) | Organism |
---|---|
on Ni2+-NTA column | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
additional information | steroidogenic cell | Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
FITC casein + H2O | - |
Homo sapiens | ? | - |
? | |
steroidogenic acute regulatory protein + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lon protease | - |
Homo sapiens |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.003 | - |
- |
Homo sapiens | clasto-lactacystin beta-lactone | |
0.02 | - |
- |
Homo sapiens | MG132 |