Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | degradation of proteins stimulates ATPase activity of lon | Escherichia coli | |
Polyphosphate | its binding within the ATPase domain of lon promotes the specific association and degradation of free ribosomal proteins | Escherichia coli |
Application | Comment | Organism |
---|---|---|
medicine | lon mediates proteolysis for the expression of virulence genes that promote mammalian cell infection | Salmonella enterica subsp. enterica serovar Typhimurium |
medicine | lon mediates proteolysis for the expression of virulence genes that promote mammalian cell infection | Brucella abortus |
additional information | plays vital roles in maintaining cellular functions by selectively eliminating misfolded, damaged and certain short-lived regulatory proteins. lon is essential for cellular homeostasis, mediating protein quality control and metabolic regulation | Escherichia coli |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADP | inhibits proteolytic activity of lon | Escherichia coli | |
MG 262 | is a potent peptide-based inhibitor | Salmonella enterica subsp. enterica serovar Typhimurium |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Brucella abortus | - |
- |
- |
Escherichia coli | - |
- |
- |
Homo sapiens | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Salmonella enterica subsp. enterica serovar Typhimurium | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA | mitochondrial lon binds preferentially to single-stranded DNA in a sequence-dependent manner | Homo sapiens | ? | - |
? | |
mitochondrial processing peptidase alpha subunit + H2O | human lon initiates substrate cleavage at surface exposed sites, lon degrades mitochondrial processing peptidase alpha subunit only when it is folded | Homo sapiens | ? | - |
? | |
ribosomal S2 protein + H2O | major lon cleavages sites within the bacterial S2 ribosomal protein located at the interior of the molecule | Escherichia coli | ? | - |
? | |
RNA | mitochondrial lon binds preferentially to single-stranded RNA in a sequence-dependent manner | Homo sapiens | ? | - |
? | |
S1 peptide + H2O | decapeptide S1 containing the amino acid residues 89-98 of the bacteriophage lambdaN transcription anti-termination factor, and a fluorescence donor-acceptor pair | Escherichia coli | ? | - |
? | |
steroidogenic acute regulatory protein + H2O | human lon initiates substrate cleavage at surface exposed sites | Homo sapiens | ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
heptamer | cryoelectron microscopy | Homo sapiens |
heptamer | cryoelectron microscopy | Saccharomyces cerevisiae |
hexamer | electron microscopy | Escherichia coli |
Synonyms | Comment | Organism |
---|---|---|
ATP-dependent lon protease | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
ATP-dependent lon protease | - |
Escherichia coli |
ATP-dependent lon protease | - |
Homo sapiens |
ATP-dependent lon protease | - |
Saccharomyces cerevisiae |
ATP-dependent lon protease | - |
Brucella abortus |
lon | - |
Homo sapiens |
lon | - |
Saccharomyces cerevisiae |
lon protease | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
lon protease | - |
Escherichia coli |
lon protease | - |
Homo sapiens |
lon protease | - |
Saccharomyces cerevisiae |
lon protease | - |
Brucella abortus |
Pim1p | - |
Saccharomyces cerevisiae |
Protease La | - |
Salmonella enterica subsp. enterica serovar Typhimurium |
Protease La | - |
Escherichia coli |
Protease La | - |
Homo sapiens |
Protease La | - |
Saccharomyces cerevisiae |
Protease La | - |
Brucella abortus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Escherichia coli |