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Literature summary for 3.4.21.53 extracted from
- Importance of the lon protease in mitochondrial maintenance and the significance of declining lon in aging (2007), Ann. N. Y. Acad. Sci., 1119, 78-87.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| additional information | in heart mitochondria, lon expression increases with age, its ATP-stimulated activity remains the same in young and old cells | Rattus norvegicus |
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | lon and aconitase may be key players in the maintenance of mitochondrial homeostasis under conditions of stress, partial compromise of their function may contribute to both aging and degenerative diseases | Homo sapiens |
| medicine | lon downregulation may contribute to the aging process | Mus musculus |
| medicine | lon downregulation may contribute to the aging process | Rattus norvegicus |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| ATP | inhibits DNA binding by lon | Homo sapiens |  |
| additional information | lon protease expression and activity declines with age | Homo sapiens | |
| additional information | Lon protease expression and activity declines with age, steady-state levels of lon mRNA are ca. 4fold lower in 30-month-old mice than in young mice. 5fold decrease in protein levels and activity in old mice compared to young mice | Mus musculus | |
| additional information | total activity of lon decreases about 2.5fold in old liver, protein level does not change in old compared to young liver | Rattus norvegicus |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Mus musculus | 5739 | - |
| mitochondrion | matrix | Homo sapiens | 5739 | - |
| mitochondrion | matrix | Rattus norvegicus | 5739 | - |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| heart | - |
Rattus norvegicus | - |
| liver | - |
Rattus norvegicus | - |
| skeletal muscle | - |
Mus musculus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| native aconitase + H2O | degradation at a lower efficiency than oxidized aconitase | Homo sapiens | ? | - |
? | |
| oxidized aconitase + H2O | oxidatively modified proteins and unfolded peptides are good substrates for proteolysis by lon | Homo sapiens | ? | - |
? | |
| polymerase gamma + H2O | - |
Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lon | - |
Mus musculus |
| lon | - |
Homo sapiens |
| lon | - |
Rattus norvegicus |
| lon protease | - |
Mus musculus |
| lon protease | - |
Homo sapiens |
| lon protease | - |
Rattus norvegicus |
| lonA | - |
Mus musculus |
| lonA | - |
Homo sapiens |
| lonA | - |
Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| ATP | - |
Homo sapiens | |
| ATP | - |
Rattus norvegicus | |
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Release 2023.1 (January 2023)
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