Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | in heart mitochondria, lon expression increases with age, its ATP-stimulated activity remains the same in young and old cells | Rattus norvegicus |
Application | Comment | Organism |
---|---|---|
medicine | lon and aconitase may be key players in the maintenance of mitochondrial homeostasis under conditions of stress, partial compromise of their function may contribute to both aging and degenerative diseases | Homo sapiens |
medicine | lon downregulation may contribute to the aging process | Mus musculus |
medicine | lon downregulation may contribute to the aging process | Rattus norvegicus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ATP | inhibits DNA binding by lon | Homo sapiens | |
additional information | lon protease expression and activity declines with age | Homo sapiens | |
additional information | Lon protease expression and activity declines with age, steady-state levels of lon mRNA are ca. 4fold lower in 30-month-old mice than in young mice. 5fold decrease in protein levels and activity in old mice compared to young mice | Mus musculus | |
additional information | total activity of lon decreases about 2.5fold in old liver, protein level does not change in old compared to young liver | Rattus norvegicus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
mitochondrion | matrix | Homo sapiens | 5739 | - |
mitochondrion | matrix | Rattus norvegicus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Rattus norvegicus | - |
liver | - |
Rattus norvegicus | - |
skeletal muscle | - |
Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
native aconitase + H2O | degradation at a lower efficiency than oxidized aconitase | Homo sapiens | ? | - |
? | |
oxidized aconitase + H2O | oxidatively modified proteins and unfolded peptides are good substrates for proteolysis by lon | Homo sapiens | ? | - |
? | |
polymerase gamma + H2O | - |
Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lon | - |
Mus musculus |
lon | - |
Homo sapiens |
lon | - |
Rattus norvegicus |
lon protease | - |
Mus musculus |
lon protease | - |
Homo sapiens |
lon protease | - |
Rattus norvegicus |
lonA | - |
Mus musculus |
lonA | - |
Homo sapiens |
lonA | - |
Rattus norvegicus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Homo sapiens | |
ATP | - |
Rattus norvegicus |