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Literature summary for 3.4.21.53 extracted from

  • Ondrovicova, G.; Liu, T.; Singh, K.; Tian, B.; Li, H.; Gakh, O.; Perecko, D.; Janata, J.; Granot, Z.; Orly, J.; Kutejova, E.; Suzuki, C.K.
    Cleavage site selection within a folded substrate by the ATP-dependent Lon protease (2005), J. Biol. Chem., 280, 25103-25110.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
ATP
-
Saccharomyces cerevisiae
ATP human mitochondrial lon degrades mouse StAR in the presence of ATP, but not in its absence Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
-
Homo sapiens 5739
-
mitochondrion
-
Saccharomyces cerevisiae 5739
-

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
human lon is overproduced and purified from the Rosetta Escherichia coli strain. Human mitochondrial lon degrades mouse StAR in the presence of ATP, but not in its absence Homo sapiens
overproduced and purified from isolated yeast mitochondria Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
mitochondrial processing peptidase alpha-subunit + H2O
-
Saccharomyces cerevisiae ?
-
?
additional information enzyme recognizes specific surface determinants or folds, initiates proteolysis at solvent-accessible sites, and generates unfolded polypeptides that are then processively degraded Saccharomyces cerevisiae ?
-
?
MPPalpha + H2O mitochondrial processing peptidase alpha-subunit (MPPalpha), to show that mitochondrial Lon also degrades folded proteins and initiates substrate cleavage non-processively. Two mitochondrial substrates with known or homology-derived three-dimensional structures are used Homo sapiens ?
-
?
MPPalpha + H2O mitochondrial processing peptidase alpha-subunit (MPPalpha), to show that mitochondrial Lon also degrades folded proteins and initiates substrate cleavage non-processively. Two mitochondrial substrates with known or homology-derived three-dimensional structures are used Saccharomyces cerevisiae ?
-
?
StAR + H2O steroidogenic acute regulatory protein (StAR), to show that mitochondrial Lon also degrades folded proteins and initiates substrate cleavage non-processively. Two mitochondrial substrates with known or homology-derived three-dimensional structures are used Homo sapiens ?
-
?
StAR + H2O steroidogenic acute regulatory protein (StAR), to show that mitochondrial Lon also degrades folded proteins and initiates substrate cleavage non-processively. Two mitochondrial substrates with known or homology-derived three-dimensional structures are used Saccharomyces cerevisiae ?
-
?
steroidogenic acute regulatory protein + H2O
-
Saccharomyces cerevisiae ?
-
?

Synonyms

Synonyms Comment Organism
lon
-
Homo sapiens
lon
-
Saccharomyces cerevisiae
lon protease
-
Homo sapiens
lon protease
-
Saccharomyces cerevisiae