Activating Compound | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Saccharomyces cerevisiae | |
ATP | human mitochondrial lon degrades mouse StAR in the presence of ATP, but not in its absence | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Homo sapiens | 5739 | - |
mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Saccharomyces cerevisiae | - |
- |
- |
Purification (Comment) | Organism |
---|---|
human lon is overproduced and purified from the Rosetta Escherichia coli strain. Human mitochondrial lon degrades mouse StAR in the presence of ATP, but not in its absence | Homo sapiens |
overproduced and purified from isolated yeast mitochondria | Saccharomyces cerevisiae |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
mitochondrial processing peptidase alpha-subunit + H2O | - |
Saccharomyces cerevisiae | ? | - |
? | |
additional information | enzyme recognizes specific surface determinants or folds, initiates proteolysis at solvent-accessible sites, and generates unfolded polypeptides that are then processively degraded | Saccharomyces cerevisiae | ? | - |
? | |
MPPalpha + H2O | mitochondrial processing peptidase alpha-subunit (MPPalpha), to show that mitochondrial Lon also degrades folded proteins and initiates substrate cleavage non-processively. Two mitochondrial substrates with known or homology-derived three-dimensional structures are used | Homo sapiens | ? | - |
? | |
MPPalpha + H2O | mitochondrial processing peptidase alpha-subunit (MPPalpha), to show that mitochondrial Lon also degrades folded proteins and initiates substrate cleavage non-processively. Two mitochondrial substrates with known or homology-derived three-dimensional structures are used | Saccharomyces cerevisiae | ? | - |
? | |
StAR + H2O | steroidogenic acute regulatory protein (StAR), to show that mitochondrial Lon also degrades folded proteins and initiates substrate cleavage non-processively. Two mitochondrial substrates with known or homology-derived three-dimensional structures are used | Homo sapiens | ? | - |
? | |
StAR + H2O | steroidogenic acute regulatory protein (StAR), to show that mitochondrial Lon also degrades folded proteins and initiates substrate cleavage non-processively. Two mitochondrial substrates with known or homology-derived three-dimensional structures are used | Saccharomyces cerevisiae | ? | - |
? | |
steroidogenic acute regulatory protein + H2O | - |
Saccharomyces cerevisiae | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
lon | - |
Homo sapiens |
lon | - |
Saccharomyces cerevisiae |
lon protease | - |
Homo sapiens |
lon protease | - |
Saccharomyces cerevisiae |