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Literature summary for 3.4.21.53 extracted from
- Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism (2002), Nat. Cell Biol., 4, 674-680.
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| mitochondrion | - |
Homo sapiens | 5739 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| mitochondrial aconitase + H2O | Homo sapiens | essential enzyme, particularly susceptible to oxidative damage, preferentially oxidatively modified and inactivated during ageing | ? | - |
? |  |
| additional information | Homo sapiens | ATP stimulated protease may be an essential defence against the stress of life in an oxygen environment | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
human,WI-38 VA-13 cell line | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Homo sapiens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| mitochondrial aconitase + H2O | essential enzyme, particularly susceptible to oxidative damage, preferentially oxidatively modified and inactivated during ageing | Homo sapiens | ? | - |
? | |
| additional information | ATP stimulated protease may be an essential defence against the stress of life in an oxygen environment | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| lon | - |
Homo sapiens |
| lon protease | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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