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Literature summary for 3.4.21.53 extracted from

  • Hilliard, J.J.; Simon, L.D.; Van Melderen, L.; Maurizi, M.R.
    PinA inhibits ATP hydrolysis and energy-dependent protein degradation by Lon protease (1998), J. Biol. Chem., 273, 524-527.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
bacteriophage T4 PinA protein inhibits degradation of alpha-methyl-casein and CcdA, noncompetitive inhibition, no inhibition of cleavage of N-glutaryl-alanylalanylphenylalanyl-3-methoxynaphthylamide Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
87000
-
? * 87000 Escherichia coli

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
alpha-methyl casein + H2O
-
Escherichia coli ?
-
?
CcdA + H2O 72-amino acid protein Escherichia coli ?
-
?
lambda phage N protein + H2O
-
Escherichia coli ?
-
?
N-glutaryl-alanylalanylphenylalanyl-3-methoxynaphthylamide + H2O fluorogenic petide Escherichia coli ?
-
?

Subunits

Subunits Comment Organism
oligomer ? * 87000 Escherichia coli

Synonyms

Synonyms Comment Organism
lon protease
-
Escherichia coli

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0000036
-
bacteriophage T4 PinA protein pH 8.0, 25°C, inhibition of casein hydrolysis Escherichia coli