Inhibitors | Comment | Organism | Structure |
---|---|---|---|
Y-27632 | attenuates thrombin-mediated phosphorylation of p38MAPK and p65 | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
fibrinogen + H2O | Homo sapiens | - |
fibrin + fibrinopeptide A + fibrinopeptide B | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
proteolytic modification | active thrombin is generated from thrombinogen by proteolytic cleavage | Homo sapiens |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
commercial preparation | - |
Homo sapiens | - |
vascular endothelial cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
fibrinogen + H2O | - |
Homo sapiens | fibrin + fibrinopeptide A + fibrinopeptide B | - |
? |
General Information | Comment | Organism |
---|---|---|
physiological function | Thrombin is a multifunctional serine protease generated by the cleavage of prothrombin at sites of vascular injury, and promotes the conversion of fibrinogen to fibrin. thrombin induces monocyte chemoattractant protein 1, MCP-1, expression through Rho-kinase and subsequent p38MAPK/NF-kappaB signaling pathway activation in vascular endothelial cells leading to the development of atherosclerosis, the Rho/Rho-kinase signaling pathway plays a critical role in thrombin-mediated MCP-1 expression and function, Rho-kinase mediates thrombin-induced MCP-1 expression through p38MAPK and NF-jB activation, mechanism, overview | Homo sapiens |