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Literature summary for 3.4.21.5 extracted from

  • Gambaryan, S.; Kobsar, A.; Rukoyatkina, N.; Herterich, S.; Geiger, J.; Smolenski, A.; Lohmann, S.M.; Walter, U.
    Thrombin and collagen induce a feedback inhibitory signaling pathway in platelets involving dissociation of the catalytic subunit of protein kinase A from an NFkappaB-IkappaB complex (2010), J. Biol. Chem., 285, 18352-18363.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fibrinogen + H2O Homo sapiens
-
 fibrin + fibrinopeptide A + fibrinopeptide B
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fibrinogen + H2O
-
 Homo sapiens fibrin + fibrinopeptide A + fibrinopeptide B
-
 ?

General Information

General Information Comment Organism
physiological function in thrombin- and collagen-stimulated platelets, protein kinase A is activated by cAMP-independent mechanisms involving dissociation of the catalytic subunit of protein kinase A from an nuclear factor kappaB-IkappaBalpha-catalytic subunit of protein kinase complex. Thrombin and collagen cause platelet activation and fine-tune this response by initiating downstream nuclear factor kappaB-dependent protein kinase A catalytic subunit activation, as a novel feedback inhibitory signaling mechanism for preventing undesired platelet activation Homo sapiens