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Literature summary for 3.4.21.5 extracted from

  • Yoshikawa, Y.; Hirayasu, H.; Tsuzuki, S.; Fushiki, T.
    Granzyme A and thrombin differentially promote the release of interleukin-8 from alveolar epithelial A549 cells (2010), Cytotechnology, 62, 325-332.
    View publication on PubMedView publication on EuropePMC
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
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 Homo sapiens
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General Information

General Information Comment Organism
physiological function thrombin promotes the release of interleukin-8 from alveolar epithelial A549 cells via a mechanism partially involving activation of protease-activated receptor-1, maximal interleukin-8 release is observed in cells incubated with serum-free medium containing 25 nM thrombin (3.6fold increase compared to cells incubated with serum-free medium alone) Homo sapiens