Activating Compound | Comment | Organism | Structure |
---|---|---|---|
factor Xa | active factor Xa hydrolyzes and activates prothrombin to thrombin | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ARH-067637 | the prodrug AZD-0837 is bioactively converted into the direct thrombin inhibitor ARH-067637 | Homo sapiens | |
AZD-0837 | direct thrombin inhibitor, the prodrug AZD-0837 is bioactively converted into the direct thrombin inhibitor ARH-067637 | Homo sapiens | |
dabigatran | specific, competitive and reversible inhibitor of thrombin, dabigatran binds to the active site of thrombin via hydrophobic interactions and can inhibit both free and fibrin-bound thrombin | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
fibrinogen + H2O | Homo sapiens | - |
fibrin + fibrinopeptide A + fibrinopeptide B | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
fibrinogen + H2O | - |
Homo sapiens | fibrin + fibrinopeptide A + fibrinopeptide B | - |
? |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000045 | - |
dabigatran | - |
Homo sapiens |