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Literature summary for 3.4.21.5 extracted from

  • Verghese, J.; Liang, A.; Sidhu, P.P.; Hindle, M.; Zhou, Q.; Desai, U.R.
    First steps in the direction of synthetic, allosteric, direct inhibitors of thrombin and factor Xa (2009), Bioorg. Med. Chem. Lett., 19, 4126-4129.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
3-(3-ethoxy-3-oxopropyl)-6-methoxy-2-methyl-1-benzofuran-5-yl sulfate
-
Homo sapiens
3-(ethoxycarbonyl)-2-methyl-1-benzofuran-5,6-diyl disulfate
-
Homo sapiens
3-(ethoxycarbonyl)-5-methoxy-2-methyl-1-benzofuran-6-yl sulfate
-
Homo sapiens
3-(ethoxycarbonyl)-6-methoxy-2-methyl-1-benzofuran-5-yl sulfate
-
Homo sapiens
3-(hydroxymethyl)-6-methoxy-2-methyl-1-benzofuran-5-ol
-
Homo sapiens
3-carboxy-2-methyl-1-benzofuran-5,6-diyl disulfate about 70% inhibition at 2.6 mM Homo sapiens
3-carboxy-5-methoxy-2-methyl-1-benzofuran-6-yl sulfate about 80% inhibition at 2.6 mM Homo sapiens
3-carboxy-6-methoxy-2-methyl-1-benzofuran-5-yl sulfate about 40% inhibition at 2.6 mM Homo sapiens
5,6-dihydroxy-2-methyl-1-benzofuran-3-carboxylic acid about 20% inhibition at 2.6 mM Homo sapiens
5-hydroxy-6-methoxy-2-methyl-1-benzofuran-3-carboxylic acid about 25% inhibition at 2.6 mM Homo sapiens
Cds03 CdsO3 binds to exosite II of thrombin to allosterically disrupt the catalytic apparatus resulting in inhibition Homo sapiens
ethyl 3-(5-hydroxy-6-methoxy-2-methyl-1-benzofuran-3-yl)propanoate
-
Homo sapiens
ethyl 5,6-dihydroxy-2-methyl-1-benzofuran-3-carboxylate
-
Homo sapiens
ethyl 5-hydroxy-6-methoxy-2-methyl-1-benzofuran-3-carboxylate
-
Homo sapiens
ethyl 6-hydroxy-5-methoxy-2-methyl-1-benzofuran-3-carboxylate
-
Homo sapiens
sodium 3-(2-carboxyethyl)-6-methoxy-2-methyl-1-benzofuran-5-yl sulfate about 35% inhibition at 2.6 mM Homo sapiens
sodium 3-(5-hydroxy-6-methoxy-2-methyl-1-benzofuran-3-yl)propanoate about 40% inhibition at 2.6 mM Homo sapiens
[6-methoxy-2-methyl-5-(sulfonatooxy)-1-benzofuran-3-yl]methyl sulfate
-
Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fibrinogen + H2O Homo sapiens
-
fibrin + fibrinopeptide A + fibrinopeptide B
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fibrinogen + H2O
-
Homo sapiens fibrin + fibrinopeptide A + fibrinopeptide B
-
?
spectrozyme TH + H2O
-
Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
alpha-thrombin
-
Homo sapiens
fibrinogenase
-
Homo sapiens