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Literature summary for 3.4.21.5 extracted from

  • Chang, C.J.; Hsu, L.A.; Ko, Y.H.; Chen, P.L.; Chuang, Y.T.; Lin, C.Y.; Liao, C.H.; Pang, J.H.
    Thrombin regulates matrix metalloproteinase-9 expression in human monocytes (2009), Biochem. Biophys. Res. Commun., 385, 241-246.
    View publication on PubMed

Organism

Organism UniProt Comment Textmining
Homo sapiens
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-
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Source Tissue

Source Tissue Comment Organism Textmining
monocyte
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Homo sapiens
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General Information

General Information Comment Organism
physiological function thrombin stimulation induces matrix metalloproteinase-9 secretion of monocytes dose- and time-dependently (0-8 units/ml thrombin), inhibition of thrombin-induced matrix metalloproteinase-9 secretion by either MEK inhibitor or p38 kinase inhibitor reveals that the thrombin effect is mediated by both ERK1/2 and p38 pathways Homo sapiens