Application | Comment | Organism |
---|---|---|
medicine | comparison of thrombin inhibitors lepirudin and argatroban for treatment of heparin-induced thrombocytopenia. Adult subjects with a positive anti-heparin platelet factor 4 antibody test and more than 50% decrease in platelet count during the first 30 days of admission over a period of 2 years were included in the study. Subjects treated with a thrombin inhibitor are more likely to experience platelet count recovery, with 87.5% for the lepirudin group and 82.4% for the argatroban group, compared to those who do not receive antithrombin therapy. The thrombosis rate for subjects who do not receive antithrombin therapy after the diagnosis of heparin-induced thrombocytopenia is 26.8%, compared to 8.3% for the lepirudin group and 5.9% for the argatroban group | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
argatroban | - |
Homo sapiens | |
lepirudin | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
patients with heparin-induced thrombocytopenia | - |