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Literature summary for 3.4.21.5 extracted from

  • Smadja, D.M.; Basire, A.; Amelot, A.; Conte, A.; Bieche, I.; Le Bonniec, B.F.; Aiach, M.; Gaussem, P.
    Thrombin bound to a fibrin clot confers angiogenic and hemostatic properties on endothelial progenitor cells (2007), J. Cell. Mol. Med., 12, 975-986.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 3.4.21.5

Metals/Ions

Metals/Ions Comment Organism Structure
Ca2+
-
 Homo sapiens
Na+
-
 Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
fibrinogen + H2O Homo sapiens
-
 fibrin + ?
-
 ?
additional information Homo sapiens thrombin is initially implicated in hemostasis and fibrin clot formation, and is also involved in cell biology since the discovery of its major receptor, the protease-activated receptor-1, PAR-1, fibrin-adsorbed thrombin interacts with endothelial progenitor cells via the thrombin receptor PAR-1, overview ?
-
 ?
protease-activated receptor-1 + H2O Homo sapiens PAR-1 is the major mediator of thrombin signalling and is involved in platelet activation, smooth muscle cells migration and proliferation, PAR-1 activation also regulates many aspects of endothelial cell biology and has been involved in vascular development ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
mononuclear cell
-
 Homo sapiens
-
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
fibrinogen + H2O
-
 Homo sapiens fibrin + ?
-
 ?
additional information thrombin is initially implicated in hemostasis and fibrin clot formation, and is also involved in cell biology since the discovery of its major receptor, the protease-activated receptor-1, PAR-1, fibrin-adsorbed thrombin interacts with endothelial progenitor cells via the thrombin receptor PAR-1, overview Homo sapiens ?
-
 ?
protease-activated receptor-1 + H2O PAR-1 is the major mediator of thrombin signalling and is involved in platelet activation, smooth muscle cells migration and proliferation, PAR-1 activation also regulates many aspects of endothelial cell biology and has been involved in vascular development Homo sapiens ?
-
 ?
protease-activated receptor-1 + H2O fibrin-bound thrombin, specific cleavage by thrombin at the extracellular N-terminus Homo sapiens ?
-
 ?
S2238 + H2O fibrin-bound thrombin activity, measured by selective chromogenic substrate S2238 Homo sapiens ?
-
 ?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens