Literature summary for 3.4.21.5 extracted from

Carter, W.J.; Myles, T.; Gibbs, C.S.; Leung, L.L.; Huntington, J.A.
Crystal structure of anticoagulant thrombin variant E217K provides insights into thrombin allostery (2004), J. Biol. Chem., 279, 26387-26394.

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Crystallization (Commentary)

Crystallization (Comment)	Organism
mutant E217K, shows repositioned E192 and destructed oxyanion hole	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
E217K	retains ability to activate the anticoagulant protein C pathway, inable to convert fibrinogen to a fibrin clot. Allosteric inactivation by destabilization of Na+ binding site, thus representing the Na+-free, catalytically slow form	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P00734	-	-

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Release 2023.1 (January 2023)