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Literature summary for 3.4.21.5 extracted from

  • Scheffler, J.E.; Berliner, L.J.
    Aspartame and aspartame derivatives effect human thrombin catalytic activity (2004), Biophys. Chem., 112, 285-291.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
acetyl-L-Asp-L-Phe biphasic inhibition Homo sapiens
Aspartame L-Asp-L-Phe methyl ester, biphasic inhibition Homo sapiens
formyl-L-Asp-L-Phe methyl ester biphasic inhibition, 80% inhibition at 2.52 mM, inhibition is reversible Homo sapiens
additional information not inhibitory: acetyl-L-Ala-L-Phe methyl ester Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
tosyl-Gly-L-Pro-L-Arg-4-nitroanilide + H2O
-
Homo sapiens tosyl-Gly-L-Pro-L-Arg + 4-nitroaniline
-
?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
98
-
Aspartame pH 7.4, 37°C Homo sapiens