Literature summary for 3.4.21.5 extracted from

Hayakawa, Y.; Hayashi, T.; Lee, J.; Srisomporn, P.; Maeda, M.; Ozawa, T.; Sakuragawa, N.
Inhibition of thrombin by sulfated polysaccharides isolated from green algae (2000), Biochim. Biophys. Acta, 1543, 86-94.

Search for more literature for 3.4.21.5

Inhibitors

Inhibitors	Comment	Organism	Structure
anti-thrombin	human, enhanced in presence of heparin and dermatan sulfate, hirudin(54-65) peptide protects	Homo sapiens
heparin cofactor II	i.e. HCII, from human plasma, recombinant mutants, mediates enzyme inhibition with heparin, dermatan sulfate and sulfated polysaccharides from green algae Chlorophyta	Homo sapiens
additional information	heparin and dermatan sulfate use different binding sites of HCII than the Chlorophyta sulfated polysaccharides, which are more effective inhibitors even with recombinant mutant HCII, that is no longer active with heparin and dermatan sulfate, overview	Homo sapiens
sulfated polysaccharides from green algae	8 different variants of Codium sp., Caulerpa okamura, Caulerpa brachypus, Monostroma nitidum and Monostrum latissimum, composition overview, inhibition is mediated by heparin cofactor HCII, hirudin(54-65) peptide protects partially, HD22, a ssDNA aptamer, also protects, allosteric inhibition mechanism	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-phenylalanyl-pipecolyl-L-arginine-4-nitroanilide + H2O	i.e. S2238, synthetic chromogenic substrate	Homo sapiens	D-phenylalanyl-pipecolyl-L-arginine + 4-nitroaniline	-	?

Synonyms

Synonyms	Comment	Organism
alpha-thrombin	-	Homo sapiens

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
additional information	-	additional information	-	Homo sapiens

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Release 2023.1 (January 2023)