Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | regulatory proteins inactivate C3/C5 convertases on host surfaces to avoid collateral tissue damage | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00751 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood plasma | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
C3 convertase | - |
Homo sapiens |
complement alternative pathway C3 convertase | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
metabolism | complement activation results in the assembly of unstable protease complexes, denominated C3/C5 convertases, leading to inflammation and lysis. Regulatory proteins inactivate C3/C5 convertases on host surfaces to avoid collateral tissue damage. On pathogen surfaces, the glycoprotein properdin stabilizes C3/C5 convertases to efficiently fight infection. The N- and C-terminal ends of adjacent monomers in properdin oligomers conform a curly vertex that holds together the AP convertase, interacting with both the C345C and vWA domains of C3b and Bb, respectively. Properdin also promotes a large displacement of the TED (thioestercontaining domain) and CUB (complement protein subcomponents C1r/C1s, urchin embryonic growth factor and bone morphogenetic protein 1) domains of C3b, which likely impairs C3-convertase inactivation by regulatory proteins | Homo sapiens |
additional information | stabilization of the complement alternative pathway C3 convertase by properdin, structural basis, overview. Complex assembly between properdin and C3 convertase by incubation of C3b, Factor B, and Factor D in the presence of properdin. The Factor B-D279G mutant increases the stability of C3 convertase. Properdin cross-Links C3b and the Bb fragment, stabilizing the C3bBb convertase, structure overview | Homo sapiens |