Literature summary for 3.4.21.47 extracted from

Hebecker, M.; Jozsi, M.
Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein (2012), J. Biol. Chem., 287, 19528-19536.

Search for more literature for 3.4.21.47

Activating Compound

Activating Compound	Comment	Organism	Structure
human complement factor H-related protein 4	CFHR 4, two isozymes A and B of 86 and 45 kDa from plasma, domain structure, overview. The protein belongs to the factor H family of plasma glycoproteins that are composed of short consensus repeat (SCR) domains. It activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein. CFHR4 binds C3b via its C-terminus, and it lacks SCRs homologous to the complement inhibitory domains of factor H and has no significant complement regulatory activities. In contrast to the complement inhibitor factor H, CFHR4 acts as an enhancer of opsonization by promoting complement activation	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
factor H	a well known inhibitor of the alternative complement pathway	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P00751	-	-

Synonyms

Synonyms	Comment	Organism
alternative pathway C3 convertase	-	Homo sapiens
C3bBb convertase	-	Homo sapiens

General Information

General Information	Comment	Organism
physiological function	Factor H-related protein 4 activates complement by serving as a platform for the assembly of alternative pathway C3 convertase via its interaction with C3b protein. Ability of CFHR4-bound C3b to bind factor B and properdin, leading to an active convertase that generates C3a and C3b from C3. The CFHR4-C3bBb convertase is less sensitive to the factor H-mediated decay compared with the C3bBb convertas. In contrast to the complement inhibitor factor H, CFHR4 acts as an enhancer of opsonization by promoting complement activation	Homo sapiens

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Release 2023.1 (January 2023)