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Literature summary for 3.4.21.47 extracted from

  • Lindorfer, M.A.; Pawluczkowycz, A.W.; Peek, E.M.; Hickman, K.; Taylor, R.P.; Parker, C.J.
    A novel approach to preventing the hemolysis of paroxysmal nocturnal hemoglobinuria: both complement-mediated cytolysis and C3 deposition are blocked by a monoclonal antibody specific for the alternative pathway of complement (2010), Blood, 115, 2283-2291.
    View publication on PubMed
Search for more literature for 3.4.21.47

Inhibitors

Inhibitors Comment Organism Structure
additional information eculizumab does not block the activity of the APC C3 convertase Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
erythrocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C3 + H2O
-
 Homo sapiens complement component C3a + complement component C3b
-
 ?
complement component C5 + H2O
-
 Homo sapiens complement component C5a + complement component C5b
-
 ?

Synonyms

Synonyms Comment Organism
alternative pathway of complement C3/C5 convertase
-
 Homo sapiens
APC C3/C5 convertase
-
 Homo sapiens