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Literature summary for 3.4.21.47 extracted from

  • Heinen, S.; Hartmann, A.; Lauer, N.; Wiehl, U.; Dahse, H.M.; Schirmer, S.; Gropp, K.; Enghardt, T.; Wallich, R.; Haelbich, S.; Mihlan, M.; Schloetzer-Schrehardt, U.; Zipfel, P.F.; Skerka, C.
    Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation (2009), Blood, 114, 2439-2447.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
complement factor H-related protein 1 0.005-0.16 mg/ml inhibits C5 convertase activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C3 + H2O
-
Homo sapiens complement component C3a + complement component C3b
-
?
complement component C5 + H2O
-
Homo sapiens complement component C5a + complement component C5b
-
?

Synonyms

Synonyms Comment Organism
C3 convertase
-
Homo sapiens
C3bBb
-
Homo sapiens
C3bBbC3b
-
Homo sapiens
C5 convertase binding of an additional C3b molecule to the C3 convertase forms the C5 convertase (C3bBbC3b) of the alternative pathway Homo sapiens