Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C3 + H2O | Homo sapiens | - |
complement component C3a + complement component C3b | - |
? | |
complement component C5 + H2O | Homo sapiens | - |
complement component C5a + complement component C5b | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00751 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
serum | - |
Homo sapiens | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
convertase formation and activity shown, Western blot, ELISA and fluorescence resonance energy transfer (FRET) used to study formation of the fluid-phase AP convertases C3(H2O)Bb and C3bBb, regulation by factor H and factor I determined, higher affinity for complement component C3(H2O) than for complement component C3b determined, convertase activity of C3bBb higher than of C3(H2O)Bb, C3(H2O)Bb convertase more resistant to inactivation by factor H and factor I than the C3bBb convertase, 25% of initial activity of complement component C3(H2O)Bb retained at conditions that totally inactivate C3bBb | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C3 + H2O | - |
Homo sapiens | complement component C3a + complement component C3b | - |
? | |
complement component C3 + H2O | studies on fluid-phase formation of initial convertase by fluorescence resonance energy transfer (FRET) | Homo sapiens | complement component C3a + complement component C3b | - |
? | |
complement component C5 + H2O | - |
Homo sapiens | complement component C5a + complement component C5b | - |
? |
Synonyms | Comment | Organism |
---|---|---|
C3 convertase | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |