Activating Compound | Comment | Organism | Structure |
---|---|---|---|
properdin | facilitates AP complement activation by stabilizing the C3 convertase C3bBb, essential for AP complement activation induced by bacterial lipopolysacharide (LPS) and lipooligosacharide (LOS) and other AP complement activators | Homo sapiens | |
properdin | facilitates AP complement activation by stabilizing the C3 convertase C3bBb, essential for AP complement activation induced by bacterial lipopolysacharide (LPS) and lipooligosacharide (LOS) and other AP complement activators | Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | studies on role of properdin in AP complement initiation for understanding the selective predisposition of properdin-deficient patients to meningococcal infection | Homo sapiens |
medicine | studies on role of properdin in AP complement initiation for understanding the selective predisposition of properdin-deficient patients to meningococcal infection | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C3 + H2O | Homo sapiens | - |
complement component C3a + complement component C3b | - |
? | |
complement component C3 + H2O | Mus musculus | - |
complement component C3a + complement component C3b | - |
? | |
complement component C5 + H2O | Homo sapiens | - |
complement component C5a + complement component C5b | - |
? | |
complement component C5 + H2O | Mus musculus | - |
complement component C5a + complement component C5b | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P00751 | - |
- |
Mus musculus | P04186 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
serum | - |
Homo sapiens | - |
serum | - |
Mus musculus | - |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
additional information | - |
ability of human properdin to restore LPS-dependent AP complement activity in properdin-deficient mouse serum shown to be correlated with the human properdin-binding affinity of the LPS | Homo sapiens |
additional information | - |
LPS- and LOS-induced AP complement activation abolished in properdin-deficient mouse serum, zymosan- and cobra venom factor-induced AP complement activation observed, classical pathway-triggered AP complement amplification only partially or minimally affected in properdin-deficient mice, ability of human properdin to restore LPS-dependent AP complement activity in properdin-deficient mouse serum shown to be correlated with the human properdin-binding affinity of the LPS | Mus musculus |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C3 + H2O | - |
Homo sapiens | complement component C3a + complement component C3b | - |
? | |
complement component C3 + H2O | - |
Mus musculus | complement component C3a + complement component C3b | - |
? | |
complement component C3 + H2O | complement activation in properdin-deficient mice analyzed | Mus musculus | complement component C3a + complement component C3b | - |
? | |
complement component C3 + H2O | properdin-deficient patients susceptible to lethal meningococcal infection, studies on yet unknown mechanism of selective predisposition | Homo sapiens | complement component C3a + complement component C3b | - |
? | |
complement component C5 + H2O | - |
Homo sapiens | complement component C5a + complement component C5b | - |
? | |
complement component C5 + H2O | - |
Mus musculus | complement component C5a + complement component C5b | - |
? |
Synonyms | Comment | Organism |
---|---|---|
alternative-complement-pathway C3/C5 convertase | - |
Homo sapiens |
alternative-complement-pathway C3/C5 convertase | - |
Mus musculus |