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Literature summary for 3.4.21.47 extracted from

  • Moller-Kristensen, M.; Thiel, S.; Sjoeholm, A.; Matsushita, M.; Jensenius, J.C.
    Cooperation between MASP-1 and MASP-2 in the generation of C3 convertase through the MBL pathway (2007), Int. Immunol., 19, 141-149.
    View publication on PubMed
Search for more literature for 3.4.21.47

Activating Compound

Activating Compound Comment Organism Structure
mannan-binding lectin mannan-binding lectin (MBL) promotes activation of complement component C3 through the combined action of MBL-associated serine proteases MASP-1 and MASP-2 without appreciable involvement of the alternative pathway Mus musculus
mannan-binding lectin mannan-binding lectin (MBL) promotes activation of complement component C3 through the combined action of MBL-associated serine proteases MASP-1 and MASP-2 without appreciable involvement of the alternative pathway, experimental conditions described Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C3 + H2O Homo sapiens
-
 complement component C3a + complement component C3b
-
 ?
complement component C3 + H2O Mus musculus
-
 complement component C3a + complement component C3b
-
 ?
complement component C5 + H2O Homo sapiens
-
 complement component C5a + complement component C5b
-
 ?
complement component C5 + H2O Mus musculus
-
 complement component C5a + complement component C5b
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens P00751
-
-
Mus musculus P04186
-
-

Source Tissue

Source Tissue Comment Organism Textmining
serum C3 knock-out mice used as an assay control, serum from MBL double-KO mice (MBLA-/-, MBLC-/-) used to evaluate the mannan-binding lectin (MBL) pathway Mus musculus
-
serum human serum from B/B genotype donors deficient in mannan-binding lectin (MBL) Homo sapiens
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 complement component C3 cleavage through the mannan-binding lectin (MBL) pathway in mouse sera determined, experimental conditions described Mus musculus
additional information
-
 deposition of the solid-phase activation product complement component C3b on a mannan-coated surface at a high concentration of 17% of human serum determined, function of the proteases MASP-1 and MASP-2 in the generation of complement component C3 convertase at high but not at low serum concentrations Homo sapiens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C3 + H2O
-
 Homo sapiens complement component C3a + complement component C3b
-
 ?
complement component C3 + H2O
-
 Mus musculus complement component C3a + complement component C3b
-
 ?
complement component C3 + H2O cleavage of complement component C3 mediated through the MBL pathway in human serum analyzed, mannan-binding lectin (MBL) promotes activation of C3, combined action of MBL-associated serine proteases MASP-1 and MASP-2 required, involvement of the alternative pathway not detected Homo sapiens complement component C3a + complement component C3b
-
 ?
complement component C3 + H2O cleavage of complement component C3 through the mannan-binding lectin pathway in mouse sera determined Mus musculus complement component C3a + complement component C3b
-
 ?
complement component C5 + H2O
-
 Homo sapiens complement component C5a + complement component C5b
-
 ?
complement component C5 + H2O
-
 Mus musculus complement component C5a + complement component C5b
-
 ?

Synonyms

Synonyms Comment Organism
C3 convertase
-
 Homo sapiens
C3 convertase
-
 Mus musculus