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Literature summary for 3.4.21.47 extracted from

  • Hourcade, D.E.; Mitchell, L.; Kuttner-Kondo, L.A.; Atkinson, J.P.; Medof, M.E.
    Decay-accelerating factor (DAF), complement receptor 1 (CR1), and factor H dissociate the complement AP C3 convertase (C3bBb) via sites on the type A domain of Bb (2002), J. Biol. Chem., 277, 1107-1112.
    View publication on PubMed
Search for more literature for 3.4.21.47

Protein Variants

Protein Variants Comment Organism
D254G mutation in the Bb component decreases sensitivity to DAF to 9% of the wild-type value, sensitivity to CR1 to 4% of the wild-type value and sensitivity to Factor H to 48% of the wild-type value Homo sapiens
D382A mutation in the Bb component decreases sensitivity to DAF to 36% of the wild-type value, sensitivity to CR1 to 41% of the wild-type value Homo sapiens
D382N mutation in the Bb component decreases sensitivity to DAF to 54% of the wild-type value Homo sapiens
D445A mutation in the Bb component decreases sensitivity to CR1 to 71% of the wild-type value Homo sapiens
E301A mutation in the Bb component decreases sensitivity to DAF to 75% of the wild-type value Homo sapiens
E316A mutation in the Bb component decreases sensitivity to DAF to 71% of the wild-type value Homo sapiens
E379A mutation in the Bb component decreases sensitivity to DAF to 52% of the wild-type value, sensitivity to CR1 to 50% of the wild-type value Homo sapiens
E434A mutation in the Bb component decreases sensitivity to CR1 to 65% of the wild-type value Homo sapiens
K265A/K266A Mutation in the Bb component decreases sensitivity to DAF to 18% of the wild-type value, sensitivity to CR1 to 18% of the wild-type value and sensitivity to Factor H to 19% of the wild-type value Homo sapiens
K294A mutation in the Bb component decreases sensitivity to CR1 to 44% of the wild-type value Homo sapiens
M341A mutation in the Bb component decreases sensitivity to Factor H to 75% of the wild-type value Homo sapiens
N260D mutation in the Bb component decreases sensitivity to DAF to 32% of the wild-type value, sensitivity to CR1 to 31% of the wild-type value and sensitivity to Factor H to 24% of the wild-type value Homo sapiens
Q335A mutation in the Bb component decreases sensitivity to DAF to 20% of the wild-type value Homo sapiens
S339A mutation in the Bb component decreases sensitivity to DAF to 32% of the wild-type value, sensitivity to CR1 to 50% of the wild-type value Homo sapiens
W343A mutation in the Bb component decreases sensitivity to DAF to 55% of the wild-type value, sensitivity to CR1 to 56% of the wild-type value Homo sapiens
Y338A mutation in the Bb component decreases sensitivity to DAF to 9% of the wild-type value, sensitivity to CR1 to 4% of the wild-type value and sensitivity to Factor H to 48% of the wild-type value Homo sapiens
Y338F mutation in the Bb component decreases sensitivity to DAF to 18% of the wild-type value, sensitivity to CR1 to 20% of the wild-type value and sensitivity to Factor H to 61% of the wild-type value Homo sapiens
Y338S mutation in the Bb component decreases sensitivity to DAF to 5% of the wild-type value, sensitivity to CR1 to 24% of the wild-type value Homo sapiens

General Stability

General Stability Organism
the enzyme is subject to irreversible dissociation by three proteins: DAF, CR1 and factor H Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Synonyms

Synonyms Comment Organism
C3bBb
-
 Homo sapiens