Literature summary for 3.4.21.46 extracted from

Ming, J.; Zhang, Q.; Qiu, X.; Wang, E.
Interleukin 7/interleukin 7 receptor induce c-Fos/c-Jun-dependent vascular endothelial growth factor-D up-regulation: a mechanism of lymphangiogenesis in lung cancer (2009), Eur. J. Cancer, 45, 866-873.

Search for more literature for 3.4.21.46

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
A-549 cell	-	Homo sapiens	-
NCI-H460 cell	-	Homo sapiens	-
SK-MES-1 cell	-	Homo sapiens	-

Expression

Organism	Comment	Expression
Homo sapiens	in lung cancer cell lines, interleukin-7/interleukin-7 receptor increase the expression of VEGF-D and phosphorylation of c-Fos/c-Jun, induce c-Fos and c-Jun heterodimer formation, and enhance c-Fos/c-Jun DNA binding activity to regulate VEGF-D expression	up

General Information

General Information	Comment	Organism
physiological function	interleukin-7/interleukin-7R induce VEGF-D up-regulation and promote lymphangiogenesis via c-Fos/c-Jun pathway in lung cancer	Homo sapiens

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)