Cloned (Comment) | Organism |
---|---|
expressed in breast cancer cell lines MDA-MB-468 and MCF-7 cells | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
breast cancer cell line | PDGF-D high-expressing breast cancer cell line SUM-149 is more invasive compared to low-expressing cell lines | Homo sapiens | - |
MCF-7 cell | low PDGF-D expressing breast cancer cell line is less invasive | Homo sapiens | - |
MDA-MB-231 cell | PDGF-D expressing breast cancer cell lines are more invasive compared to non-expressing cell lines | Homo sapiens | - |
MDA-MB-468 cell | low PDGF-D expressing breast cancer cell line is less invasive | Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
PDGF-D | - |
Homo sapiens |
Organism | Comment | Expression |
---|---|---|
Homo sapiens | silencing the expression of PDGF-D by siRNA in PDGF-D high expressing MDA-MB-231 and SUM-149 cells shows decreased cell proliferation and increased apoptosis | down |
Homo sapiens | overexpression of PDGF-D in PDGF-D low expressing breast cancer cell lines MDA-MB-468 and MCF-7 cells by cDNA transfection shows increased cell proliferation. PDGF-D overexpression is positively correlated with the expression of Notch-1 and Jagged-1, and the expression of mesenchymal markers (Vimentin and ZEB-2) with concomitant decreased expression of epithelial marker E-cadherin. PDGF-D over-expression leads to increased DNA binding activity of NF-kappaB | up |
General Information | Comment | Organism |
---|---|---|
physiological function | PDGF-D plays an important role in breast tumor aggressiveness and this process is mechanistically linked with the activation of Notch and NF-kappaB signaling | Homo sapiens |