Literature summary for 3.4.21.45 extracted from

Anastasiou, V.; Mikrou, A.; Papanastasiou, A.; Zarkadis, I.
The molecular identification of factor H and factor I molecules in rainbow trout provides insights into complement C3 regulation (2011), Fish Shellfish Immunol., 31, 491-499.

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Cloned(Commentary)

Cloned (Comment)	Organism
-	Oncorhynchus mykiss

Organism

Organism	UniProt	Comment	Textmining
Oncorhynchus mykiss	E7BAR3	-	-

Posttranslational Modification

Posttranslational Modification	Comment	Organism
glycoprotein	sequence contains three potential N-glycosylation sites	Oncorhynchus mykiss
proteolytic modification	CFI mRNA is translated in both a heavy and light chain which is further cleaved at a tetrapeptide processing site	Oncorhynchus mykiss

Source Tissue

Source Tissue	Comment	Organism	Textmining
brain	low level of mRNA expression	Oncorhynchus mykiss	-
intestine	high level of mRNA expression	Oncorhynchus mykiss	-
liver	high level of mRNA expression	Oncorhynchus mykiss	-
additional information	no expression detected in heart, kidney and spleen	Oncorhynchus mykiss	-

Subunits

Subunits	Comment	Organism
More	CFI mRNA is translated in both a heavy and light chain which is further cleaved at a tetrapeptide processing site. The light chain of trout CFI comprises the serine protease domain, which contains the catalytic triad, His380-Asp429-Ser525 residues, human CFI numbering, as well as the Asp519 residue located at the bottom of the specificity pocket. All these residues are identical by composition and position in all species tested	Oncorhynchus mykiss

Synonyms

Synonyms	Comment	Organism
CFI	-	Oncorhynchus mykiss

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Release 2023.1 (January 2023)