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Literature summary for 3.4.21.45 extracted from

  • Wang, J.; Ohno-Matsui, K.; Yoshida, T.; Kojima, A.; Shimada, N.; Nakahama, K.; Safranova, O.; Iwata, N.; Saido, T.C.; Mochizuki, M.; Morita, I.
    Altered function of factor I caused by amyloid beta: implication for pathogenesis of age-related macular degeneration from Drusen (2008), J. Immunol., 181, 712-720.
    View publication on PubMed
Search for more literature for 3.4.21.45

Application

Application Comment Organism
medicine amyloid beta activates the complement system within drusen by blocking the function of factor I leading to a low-grade, chronic inflammation in subretinal tissues Mus musculus
medicine amyloid beta activates the complement system within drusen by blocking the function of factor I leading to a low-grade, chronic inflammation in subretinal tissues Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
amyloid beta binds to complement factor I which inhibits the ability of factor I to cleave C3b to inactivated C3b. Addition of factor I restores inactivated C3b production in amyloid beta-treated RPE cells. Preincubation of factor I with amyloid beta in the presence of factor H abolishes the ability of factor I to cleave FGR-7-amino-4-methylcoumarin Homo sapiens
amyloid beta production of inactivated C3b is significantly decreased when C3b and factor H are incubated with eyes from neprilysin gene-disrupted mice, which leads to an increased deposition of amyloid beta, compared with when C3b and factor H are incubated with eyes from wild-type mice Mus musculus

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
88000
-
 coimmunoprecipitation analysis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-
Mus musculus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
eye RPE-Bruch's membrane-choriocapillaris complex from eyes of 12-month-old neprilysin gene-disrupted mice and age-matched wild-type mice Mus musculus
-
additional information RPE cell Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C3b + H2O
-
 Mus musculus inactivated C3b + ?
-
 ?
complement component C3b + H2O factor I mediates cleavage of C3b between Arg1298 and Ser1299 Homo sapiens inactivated C3b + ?
-
 ?
FGR-7-amido-4-methylcoumarin + H2O
-
 Homo sapiens FGR + 7-amino-4-methylcoumarin
-
 ?

Synonyms

Synonyms Comment Organism
factor I
-
 Mus musculus
factor I
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
additional information factor H Mus musculus
additional information factor H Homo sapiens