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Literature summary for 3.4.21.45 extracted from
- Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice (2008), J. Clin. Invest., 118, 608-618.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | studies on inflammatory kidney disease membranoproliferative glomerulonephritis type II (MPGN2) | Mus musculus |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli, generation of mice strains deficient of complement factor I | Mus musculus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 88000 | - |
SDS-PAGE, nonreducing conditions, detection of murine complement factor I by using a crossreactive polyclonal goat antibody against human complement factor I | Mus musculus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| complement component C3b + H2O | Mus musculus | - |
complement component C3c + ? | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Mus musculus | Q61129 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| gel filtration | Mus musculus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| plasma | renal transplantation studies of mice included | Mus musculus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
complement component C3 level measured in plasma, glomerular complement component C3 staining and complement profile in mice with deficiency of complement factor I indicated | Mus musculus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| complement component C3b + H2O | - |
Mus musculus | complement component C3c + ? | - |
? | |
| complement component C3b + H2O | studies on membranoproliferative glomerulonephritis, potential relation to complement factor I analyzed | Mus musculus | complement component C3c + ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| heterodimer | - |
Mus musculus |
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Release 2023.1 (January 2023)
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