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Literature summary for 3.4.21.43 extracted from

  • Ramos, T.N.; Darley, M.M.; Weckbach, S.; Stahel, P.F.; Tomlinson, S.; Barnum, S.R.
    The C5 convertase is not required for activation of the terminal complement pathway in murine experimental cerebral malaria (2012), J. Biol. Chem., 287, 24734-24738.
    View publication on PubMedView publication on EuropePMC

Organism

Organism UniProt Comment Textmining
Mus musculus
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-
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Synonyms

Synonyms Comment Organism
C5 convertase
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Mus musculus

General Information

General Information Comment Organism
physiological function neither the classical nor the alternative complement pathways are required for disease development of experimental cerebral malaria. C3-/- mice develop severe experimental cerebral malaria through activation of C5 independent of complement C5 convertases by terminal pathway activation. C5 is activated in experimental cerebral malaria through the extrinsic protease pathway, overview. C5-/- mice are highly resistant to experimental cerebral malaria Mus musculus