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Literature summary for 3.4.21.43 extracted from

  • Rawal, N.; Rajagopalan, R.; Salvi, V.P.
    Activation of complement component C5: comparison of C5 convertases of the lectin pathway and the classical pathway of complement (2008), J. Biol. Chem., 283, 7853-7863.
    View publication on PubMed
Search for more literature for 3.4.21.43

Activating Compound

Activating Compound Comment Organism Structure
additional information complement activation via the lectin pathway on zymosan particles is at least 4times more efficient than via the classical pathway on sheep erythrocytes coated with antibody. Every C4b deposited via the lectin pathway is capable of forming a convertase in contrast to only one of four C4b molecules deposited via the classical pathway. Rate of formation of lectin pathway C3/C5 convertases depends on the activation of C4 and C2 by MASP-2 Homo sapiens

Application

Application Comment Organism
medicine activation of complement via the lectin pathway may be a more prominent contributor to the pathology of inflammatory reactions as compared to activation of complement via the classical pathway Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0000051
-
 complement component C5 high affinity C5 convertase (EAC1,C3bC4b,C2a) Homo sapiens
0.0056
-
 complement component C5 surface-bound C5 convertase (EAC1,C4b,C2a) Homo sapiens
0.0089
-
 complement component C5 soluble monomeric C5 convertase (C4b,C2a) Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Purification (Commentary)

Purification (Comment) Organism
complement proteins purified by gel filtration, to homogeneity Homo sapiens

Source Tissue

Source Tissue Comment Organism Textmining
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C5 + H2O
-
 Homo sapiens complement component C5a + complement component C5b
-
 ?

Synonyms

Synonyms Comment Organism
C3/C5 convertase
-
 Homo sapiens
C5 convertase
-
 Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.02
-
 complement component C5 high affinity C5 convertase (EAC1,C3bC4b,C2a) Homo sapiens
0.022
-
 complement component C5 soluble monomeric C5 convertase (C4b,C2a) Homo sapiens
0.03
-
 complement component C5 surface-bound C5 convertase (EAC1,C4b,C2a) Homo sapiens