Literature summary for 3.4.21.43 extracted from

Milder, F.J.; Raaijmakers, H.C.; Vandeputte, M.D.; Schouten, A.; Huizinga, E.G.; Romijn, R.A.; Hemrika, W.; Roos, A.; Daha, M.R.; Gros, P.
Structure of complement component C2A: implications for convertase formation and substrate binding (2006), Structure, 14, 1587-1597.

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Metals/Ions

Metals/Ions	Comment	Organism	Structure
Li+	binds to complement component C2A	Homo sapiens
Mn2+	binds to complement component C2A	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
complement component C5 + H2O	Homo sapiens	C5 convertases, C4b2a3b and C3b2Bb, cleave C5 into the anaphylatoxin C5a and C5b, overview	complement component C5a + complement component C5b	-	?
complement componentC3 + H2O	Homo sapiens	C3 convertases, C4b2a and C3bBb, cleave C3 into the anaphylatoxin C3a and C3b, overview	complement component C3a + complement component C3b	-	?
additional information	Homo sapiens	factor B associates with complement component C3b and after proteolysis yields the C3 convertase of the alternative pathway, complement component C2A provides the catalytic center to the convertase complexes of the classical and lectin-binding pathways of complement activation, structural basis of the substrate specificity of the complement complex, overview, attachment of C3b to either C4b2a or C3bBb yields the C5 convertases, C4b2a3b and C3b2Bb, respectively, that cleave complement component C5	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
complement component C5 + H2O	C5 convertases, C4b2a3b and C3b2Bb, cleave C5 into the anaphylatoxin C5a and C5b, overview	Homo sapiens	complement component C5a + complement component C5b	-	?
complement componentC3 + H2O	C3 convertases, C4b2a and C3bBb, cleave C3 into the anaphylatoxin C3a and C3b, overview	Homo sapiens	complement component C3a + complement component C3b	-	?
additional information	factor B associates with complement component C3b and after proteolysis yields the C3 convertase of the alternative pathway, complement component C2A provides the catalytic center to the convertase complexes of the classical and lectin-binding pathways of complement activation, structural basis of the substrate specificity of the complement complex, overview, attachment of C3b to either C4b2a or C3bBb yields the C5 convertases, C4b2a3b and C3b2Bb, respectively, that cleave complement component C5	Homo sapiens	?	-	?

Subunits

Subunits	Comment	Organism
More	C3 convertase complex structure including complement component C2A and the catalytic triad, crystal structure modeling, overview	Homo sapiens

Synonyms

Synonyms	Comment	Organism
C3 convertase	-	Homo sapiens
C3bBb	-	Homo sapiens
C4b2a	-	Homo sapiens
C5 convertase	-	Homo sapiens

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Release 2023.1 (January 2023)