Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C5 + H2O | Homo sapiens | C5 convertases, C4b2a3b and C3b2Bb, cleave C5 into the anaphylatoxin C5a and C5b, overview | complement component C5a + complement component C5b | - |
? | |
complement componentC3 + H2O | Homo sapiens | C3 convertases, C4b2a and C3bBb, cleave C3 into the anaphylatoxin C3a and C3b, overview | complement component C3a + complement component C3b | - |
? | |
additional information | Homo sapiens | the virion-associated Kaposis sarcoma-associated herpesvirus complement control protein is required for complement regulation and cell binding, involved structures, Kaposis sarcoma-associated herpesvirus, KSHV, encodes a lytic cycle protein called KSHV complement control protein, KCP, that inhibits activation of the complement cascade. It does so by regulating C3 convertases, accelerating their decay, and acting as a cofactor for factor I degradation of C4b and C3b, two components of the C3 and C5 convertases, KCP is expressed on the surface of human infected endothelial cells, mechanism, overview, K64Q/K65Q/K88Q KCP mutant lacks complement regulatory activity | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C5 + H2O | C5 convertases, C4b2a3b and C3b2Bb, cleave C5 into the anaphylatoxin C5a and C5b, overview | Homo sapiens | complement component C5a + complement component C5b | - |
? | |
complement componentC3 + H2O | C3 convertases, C4b2a and C3bBb, cleave C3 into the anaphylatoxin C3a and C3b, overview | Homo sapiens | complement component C3a + complement component C3b | - |
? | |
additional information | the virion-associated Kaposis sarcoma-associated herpesvirus complement control protein is required for complement regulation and cell binding, involved structures, Kaposis sarcoma-associated herpesvirus, KSHV, encodes a lytic cycle protein called KSHV complement control protein, KCP, that inhibits activation of the complement cascade. It does so by regulating C3 convertases, accelerating their decay, and acting as a cofactor for factor I degradation of C4b and C3b, two components of the C3 and C5 convertases, KCP is expressed on the surface of human infected endothelial cells, mechanism, overview, K64Q/K65Q/K88Q KCP mutant lacks complement regulatory activity | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
C3 convertase | - |
Homo sapiens |
C3b2Bb | - |
Homo sapiens |
C3bBb | - |
Homo sapiens |
C4b2a | - |
Homo sapiens |
C4b2a3b | - |
Homo sapiens |
C5 convertase | - |
Homo sapiens |