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Literature summary for 3.4.21.43 extracted from

  • Wallis, R.; Dodds, A.W.; Mitchell, D.A.; Sim, R.B.; Reid, K.B.; Schwaeble, W.J.
    Molecular interactions between MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway (2007), J. Biol. Chem., 282, 7844-7851.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
additional information molecular interactions between MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway, overview Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C5 + H2O Rattus norvegicus C5 convertases, C4b2a3b and C3b2Bb, cleave C5 into the anaphylatoxin C5a and C5b, overview complement component C5a + complement component C5b
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complement componentC3 + H2O Rattus norvegicus C3 convertases, C4b2a and C3bBb, cleave C3 into the anaphylatoxin C3a and C3b, overview complement component C3a + complement component C3b
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additional information Rattus norvegicus the enzyme catalyzes the central step of the complement cascade, overview, molecular interactions between MBL-associated serine protease-2, MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway, MASP-2 cleaves C4 releasing C4a and generating C4b, which attaches covalently to the pathogen surface upon exposure of its reactive thioester, C2 binds to C4b and is also cleaved by MASP-2 to form the C3 convertase C4b2a, overview ?
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Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C5 + H2O C5 convertases, C4b2a3b and C3b2Bb, cleave C5 into the anaphylatoxin C5a and C5b, overview Rattus norvegicus complement component C5a + complement component C5b
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?
complement componentC3 + H2O C3 convertases, C4b2a and C3bBb, cleave C3 into the anaphylatoxin C3a and C3b, overview Rattus norvegicus complement component C3a + complement component C3b
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?
additional information the enzyme catalyzes the central step of the complement cascade, overview, molecular interactions between MBL-associated serine protease-2, MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway, MASP-2 cleaves C4 releasing C4a and generating C4b, which attaches covalently to the pathogen surface upon exposure of its reactive thioester, C2 binds to C4b and is also cleaved by MASP-2 to form the C3 convertase C4b2a, overview Rattus norvegicus ?
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?

Synonyms

Synonyms Comment Organism
C3 convertase
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Rattus norvegicus
C4b2a
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Rattus norvegicus