Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | molecular interactions between MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway, overview | Rattus norvegicus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C5 + H2O | Rattus norvegicus | C5 convertases, C4b2a3b and C3b2Bb, cleave C5 into the anaphylatoxin C5a and C5b, overview | complement component C5a + complement component C5b | - |
? | |
complement componentC3 + H2O | Rattus norvegicus | C3 convertases, C4b2a and C3bBb, cleave C3 into the anaphylatoxin C3a and C3b, overview | complement component C3a + complement component C3b | - |
? | |
additional information | Rattus norvegicus | the enzyme catalyzes the central step of the complement cascade, overview, molecular interactions between MBL-associated serine protease-2, MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway, MASP-2 cleaves C4 releasing C4a and generating C4b, which attaches covalently to the pathogen surface upon exposure of its reactive thioester, C2 binds to C4b and is also cleaved by MASP-2 to form the C3 convertase C4b2a, overview | ? | - |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Rattus norvegicus | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C5 + H2O | C5 convertases, C4b2a3b and C3b2Bb, cleave C5 into the anaphylatoxin C5a and C5b, overview | Rattus norvegicus | complement component C5a + complement component C5b | - |
? | |
complement componentC3 + H2O | C3 convertases, C4b2a and C3bBb, cleave C3 into the anaphylatoxin C3a and C3b, overview | Rattus norvegicus | complement component C3a + complement component C3b | - |
? | |
additional information | the enzyme catalyzes the central step of the complement cascade, overview, molecular interactions between MBL-associated serine protease-2, MASP-2, C4, and C2 and their activation fragments leading to complement activation via the lectin pathway, MASP-2 cleaves C4 releasing C4a and generating C4b, which attaches covalently to the pathogen surface upon exposure of its reactive thioester, C2 binds to C4b and is also cleaved by MASP-2 to form the C3 convertase C4b2a, overview | Rattus norvegicus | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
C3 convertase | - |
Rattus norvegicus |
C4b2a | - |
Rattus norvegicus |