Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C5 + H2O | Homo sapiens | C5 convertases, C4b2a3b and C3b2Bb, cleave C5 into the anaphylatoxin C5a and C5b followed by initiation of the terminal pathway, leading to formation of lytic C5b-9 membrane attack complexes, overview | complement component C5a + complement component C5b | - |
? | |
complement componentC3 + H2O | Homo sapiens | C3 convertases, C4b2a and C3bBb, cleave C3 into the anaphylatoxin C3a and C3b, overview | complement component C3a + complement component C3b | - |
? | |
additional information | Homo sapiens | the C3 convertases, bimolecular complexes C4b2a and C3bBb, of the classical and alternative pathways are the central enzymes of the complement cascade, focused complement activation on foreign targets depends on regulatory proteins that decay the bimolecular C3 convertases, activity and regulation of complement control proteins CCP1-CCP4 as modules of the cell surface regulator, decay-accelerating factor, i.e. DAF or CD55, interaction of DAF with the convertases is mediated predominantly by two patches, one centered around Arg69 and Arg96 on CCP2 and the other around Phe148 and Leu171 on CCP3, structure, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C5 + H2O | C5 convertases, C4b2a3b and C3b2Bb, cleave C5 into the anaphylatoxin C5a and C5b followed by initiation of the terminal pathway, leading to formation of lytic C5b-9 membrane attack complexes, overview | Homo sapiens | complement component C5a + complement component C5b | - |
? | |
complement component C5 + H2O | C5 convertases, C4b2a3b and C3b2Bb, cleave C5 into the anaphylatoxin C5a and C5b, overview | Homo sapiens | complement component C5a + complement component C5b | - |
? | |
complement componentC3 + H2O | C3 convertases, C4b2a and C3bBb, cleave C3 into the anaphylatoxin C3a and C3b, overview | Homo sapiens | complement component C3a + complement component C3b | - |
? | |
additional information | the C3 convertases, bimolecular complexes C4b2a and C3bBb, of the classical and alternative pathways are the central enzymes of the complement cascade, focused complement activation on foreign targets depends on regulatory proteins that decay the bimolecular C3 convertases, activity and regulation of complement control proteins CCP1-CCP4 as modules of the cell surface regulator, decay-accelerating factor, i.e. DAF or CD55, interaction of DAF with the convertases is mediated predominantly by two patches, one centered around Arg69 and Arg96 on CCP2 and the other around Phe148 and Leu171 on CCP3, structure, overview | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
C3 convertase | - |
Homo sapiens |
C3bBb | - |
Homo sapiens |
C4b2a | - |
Homo sapiens |
Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
---|---|---|---|
37 | - |
assay at | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7.4 | - |
assay at | Homo sapiens |