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Literature summary for 3.4.21.43 extracted from

  • Kuttner-Kondo, L.A.; Dybvig, M.P.; Mitchell, L.M.; Muqim, N.; Atkinson, J.P.; Medof, M.E.; Hourcade, D.E.
    A corresponding tyrosine residue in the C2/factor B type A domain is a hot spot in the decay acceleration of the complement C3 convertases (2003), J. Biol. Chem., 278, 52386-52391.
    View publication on PubMed
Search for more literature for 3.4.21.43

Protein Variants

Protein Variants Comment Organism
Q243G C2 mutation reduces C4b2a sensitivity to decay-accelerating factor DAF to 2% of the wild-type, moderately reduces C4b2a sensitivity to complement receptor 1-A to 55% of the wild-type Homo sapiens
Y327A C2 mutation reduces C4b2a sensitivity to decay-accelerating factor DAF and to complement receptor 1-A to less than 1% of the wild-type Homo sapiens

General Stability

General Stability Organism
dissociation of the classical-complement-pathway C3/C5 convertase by the regulators decay-accelerating factor, DAF, complement receptor 1, CR1, factor H and C4-binding protein C4BP, controls the function of the enzyme. Decay acceleration mediated by DAF, C4BP and CR1 requires interaction of the alpha4/5 region of C2a with a CCO2/CCO3 site of DAF or structurally homologous sites of CR1 and C4BP Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens dissociation of the classical-complement-pathway C3/C5 convertase by the regulators decay-accelerating factor, DAF, complement receptor 1, CR1, factor H and C4-binding protein C4BP, controls the function of the enzyme. Decay acceleration mediated by DAF, C4BP and CR1 requires interaction of the alpha4/5 region of C2a with a CCP2/CCP3 site of DAF or structurally homologous sites of CR1 and C4BP ?
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Organism

Organism UniProt Comment Textmining
Homo sapiens
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information dissociation of the classical-complement-pathway C3/C5 convertase by the regulators decay-accelerating factor, DAF, complement receptor 1, CR1, factor H and C4-binding protein C4BP, controls the function of the enzyme. Decay acceleration mediated by DAF, C4BP and CR1 requires interaction of the alpha4/5 region of C2a with a CCP2/CCP3 site of DAF or structurally homologous sites of CR1 and C4BP Homo sapiens ?
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Synonyms

Synonyms Comment Organism
C4b2a
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 Homo sapiens