Protein Variants | Comment | Organism |
---|---|---|
Q243G | C2 mutation reduces C4b2a sensitivity to decay-accelerating factor DAF to 2% of the wild-type, moderately reduces C4b2a sensitivity to complement receptor 1-A to 55% of the wild-type | Homo sapiens |
Y327A | C2 mutation reduces C4b2a sensitivity to decay-accelerating factor DAF and to complement receptor 1-A to less than 1% of the wild-type | Homo sapiens |
General Stability | Organism |
---|---|
dissociation of the classical-complement-pathway C3/C5 convertase by the regulators decay-accelerating factor, DAF, complement receptor 1, CR1, factor H and C4-binding protein C4BP, controls the function of the enzyme. Decay acceleration mediated by DAF, C4BP and CR1 requires interaction of the alpha4/5 region of C2a with a CCO2/CCO3 site of DAF or structurally homologous sites of CR1 and C4BP | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | dissociation of the classical-complement-pathway C3/C5 convertase by the regulators decay-accelerating factor, DAF, complement receptor 1, CR1, factor H and C4-binding protein C4BP, controls the function of the enzyme. Decay acceleration mediated by DAF, C4BP and CR1 requires interaction of the alpha4/5 region of C2a with a CCP2/CCP3 site of DAF or structurally homologous sites of CR1 and C4BP | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | dissociation of the classical-complement-pathway C3/C5 convertase by the regulators decay-accelerating factor, DAF, complement receptor 1, CR1, factor H and C4-binding protein C4BP, controls the function of the enzyme. Decay acceleration mediated by DAF, C4BP and CR1 requires interaction of the alpha4/5 region of C2a with a CCP2/CCP3 site of DAF or structurally homologous sites of CR1 and C4BP | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
C4b2a | - |
Homo sapiens |