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Literature summary for 3.4.21.43 extracted from

  • Rawal, N.; Pangburn, M.K.
    Formation of high affinity C5 convertase of the classical pathway of complement (2003), J. Biol. Chem., 278, 38476-38483.
    View publication on PubMed
Search for more literature for 3.4.21.43

Activating Compound

Activating Compound Comment Organism Structure
C3b both the soluble form of the enzyme, C4b,C2a and the surface-bound form of the enzyme EAC1,C4b,C2a exhibit a poor affinity for the substrate C5. Very high affinity C5 convertase is generated only when the low affinity C3/C5 convertases are allowed to deposit C3b by cleaving native C3 Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0000011 0.0000083 complement component C5 37°C, high-affinity C5 convertase EAC1,C3bC4b,C2a Homo sapiens
0.0046 0.0066 complement component C5 37°C, surface bound C3/C5 convertase, EAC1,C4b,C2a Homo sapiens
0.0089
-
 complement component C5 37°C, soluble monomeric C3/C5 convertase C4b,C2a Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
blood plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
complement component C3 + H2O
-
 Homo sapiens complement component C3a + complement component C3b
-
 ?
complement component C5 + H2O
-
 Homo sapiens complement component C5a + complement component C5b
-
 ?

Synonyms

Synonyms Comment Organism
C4b,C2a soluble form of the enzyme Homo sapiens
classical pathway C3/C5 convertase
-
 Homo sapiens
EAC1,C4b,C2a surface-bound form of the enzyme Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.015 0.026 complement component C5 37°C, high-affinity C5 convertase EAC1,C3bC4b,C2a Homo sapiens
0.022
-
 complement component C5 37°C, soluble monomeric C3/C5 convertase C4b,C2a Homo sapiens
0.023 0.047 complement component C5 37°C, surface bound C3/C5 convertase, EAC1,C4b,C2a Homo sapiens