Inhibitors | Comment | Organism | Structure |
---|---|---|---|
TNT003 | a mouse monoclonal antibody targeting the CP-specific serine protease C1s. TNT003 prevents cold agglutinin-mediated deposition of complement opsonins that promote phagocytosis of red blood cells. By preventing classical pathway activation, TNT003 also prevents cold agglutinin-driven generation of anaphylatoxins | Homo sapiens |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
extracellular | - |
Homo sapiens | - |
- |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | P09871 | - |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
blood serum | - |
Homo sapiens | - |
Synonyms | Comment | Organism |
---|---|---|
serine protease C1s | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
physiological function | C1s is involved in the classical pathway of complement, whose activation is often associated with autoimmune disorders in which disease pathology is linked to the presence of an autoantibody. One such disorder is cold agglutinin disease, an autoimmune hemolytic anemia in which autoantibodies (cold agglutinins) bind to red blood cells at low temperatures. Anemia occurs as a result of autoantibody-mediated classical pathway activation on the surface of the erythrocyte, leading to the deposition of complement opsonins that drive extravascular hemolysis in the liver, overview. Classical pathway activity in cold agglutinin disease patients terminates prior to activation of the terminal cascade | Homo sapiens |