Literature summary for 3.4.21.42 extracted from

Arriaga, S.M.; Basiglio, C.L.; Mottino, A.D.; Almara, A.M.
Unconjugated bilirubin inhibits C1 esterase activity (2009), Clin. Biochem., 42, 919-921.

Search for more literature for 3.4.21.42

Activating Compound

Activating Compound	Comment	Organism	Structure
additional information	partially purified preparation of C1 esterase is activated by dilution with an equal volume of isotonic saline and subsequent incubation at 37°C for 15 min	Homo sapiens

Inhibitors

Inhibitors	Comment	Organism	Structure
unconjugated bilirubin	inhibits C1 esterase activity at pathological concentrations (above 17 micromol) and in a dose-dependent manner, due to a direct pigment-protein interaction. Maximal inhibitory activity is reached at an 85 micromol concentration. Inhibitory action exerted by unconjugated bilirubin on the classical pathway is not only due to an impairment of the interaction of the C1q subcomponent with IgM or IgG but also to a diminished enzymatic activity of the C1 esterase	Homo sapiens

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
partially purified	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
serum	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
N-acetyl-Tyr ethyl ester + H2O	-	Homo sapiens	N-acetyl-Tyr + ethanol	-	?

Synonyms

Synonyms	Comment	Organism
C1 esterase	-	Homo sapiens
C1s	-	Homo sapiens

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Release 2023.1 (January 2023)