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Literature summary for 3.4.21.42 extracted from

  • Kerr, F.K.; Thomas, A.R.; Wijeyewickrema, L.C.; Whisstock, J.C.; Boyd, S.E.; Kaiserman, D.; Matthews, A.Y.; Bird, P.I.; Thielens, N.M.; Rossi, V.; Pike, R.N.
    Elucidation of the substrate specificity of the MASP-2 protease of the lectin complement pathway and identification of the enzyme as a major physiological target of the serpin, C1-inhibitor (2008), Mol. Immunol., 45, 670-677.
    View publication on PubMed
Search for more literature for 3.4.21.42

Inhibitors

Inhibitors Comment Organism Structure
C1-inhibitor a serpin Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0077
-
 C1-inhibitor P4-P4' fragment pH 7.4, 37°C Homo sapiens
0.0136
-
 complement component C4 P4-P4' fragment pH 7.4, 37°C Homo sapiens
0.0274
-
 complement component C2 P4-P4' fragment pH 7.4, 37°C Homo sapiens
0.1369
-
 complement component C2 P4-P1 fragment pH 7.4, 37°C Homo sapiens
0.3408
-
 C1-inhibitor P4-P1 fragment pH 7.4, 37°C Homo sapiens
0.3581
-
 complement component C4 P4-P1 fragment pH 7.4, 37°C Homo sapiens

Localization

Localization Comment Organism GeneOntology No. Textmining
extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
complement component C2 + H2O Homo sapiens
-
 ?
-
 ?
complement component C4 + H2O Homo sapiens
-
 ?
-
 ?
additional information Homo sapiens C1s is the executioner protease component of the C1 complex in the classical complement pathway cleaving C2 and C4 components of the system, overview ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
commercial preparation
-
 Homo sapiens
-
plasma
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
C1-inhibitor P4-P1 fragment + H2O
-
 Homo sapiens ?
-
 ?
C1-inhibitor P4-P4' fragment + H2O
-
 Homo sapiens ?
-
 ?
complement component C2 + H2O
-
 Homo sapiens ?
-
 ?
complement component C2 P4-P1 fragment + H2O
-
 Homo sapiens ?
-
 ?
complement component C2 P4-P4' fragment + H2O
-
 Homo sapiens ?
-
 ?
complement component C4 + H2O
-
 Homo sapiens ?
-
 ?
complement component C4 P4-P1 fragment + H2O
-
 Homo sapiens ?
-
 ?
complement component C4 P4-P4' fragment + H2O
-
 Homo sapiens ?
-
 ?
additional information C1s is the executioner protease component of the C1 complex in the classical complement pathway cleaving C2 and C4 components of the system, overview Homo sapiens ?
-
 ?
additional information substrate and active site specificity of C1s in comparison to its equivalent MASP-2 of the lectin complement pathway, overview Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
C1s
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
 assay at Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.015
-
 complement component C4 P4-P4' fragment pH 7.4, 37°C Homo sapiens
0.0388
-
 C1-inhibitor P4-P4' fragment pH 7.4, 37°C Homo sapiens
0.069
-
 complement component C2 P4-P4' fragment pH 7.4, 37°C Homo sapiens
0.313
-
 C1-inhibitor P4-P1 fragment pH 7.4, 37°C Homo sapiens
0.38
-
 complement component C4 P4-P1 fragment pH 7.4, 37°C Homo sapiens
0.5
-
 complement component C2 P4-P1 fragment pH 7.4, 37°C Homo sapiens
12.89
-
 complement component C2 P4-P1 fragment pH 7.4, 37°C Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.4
-
 assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
 additional information first order rate inhibition kinetics Homo sapiens