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Literature summary for 3.4.21.42 extracted from

  • Subasinghe, N.L.; Ali, F.; Illig, C.R.; Jonathan Rudolph, M.; Klein, S.; Khalil, E.; Soll, R.M.; Bone, R.F.; Spurlino, J.C.; DesJarlais, R.L.; Crysler, C.S.; Cummings, M.D.; Morris, P.E., Jr.; Kilpatrick, J.M.; Sudhakara Babu, Y.
    A novel series of potent and selective small molecule inhibitors of the complement component C1s (2004), Bioorg. Med. Chem. Lett., 14, 3043-3047.
    View publication on PubMed
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Application

Application Comment Organism
medicine the enzyme represents a pivotal upstream point of control in the classical pathway of complement activation and is therefore likely to be a useful target in the therapeutic intervention of diseases like hereditary angioedema, ischemia-reperfusion injury and acute transplant rejection Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information optimization of thiopheneamidine-based inhibitors Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens the enzyme represents a pivotal upstream point of control in the classical pathway of complement activation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information the enzyme represents a pivotal upstream point of control in the classical pathway of complement activation Homo sapiens ?
-
 ?

Synonyms

Synonyms Comment Organism
protease C1s
-
 Homo sapiens