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Literature summary for 3.4.21.41 extracted from

  • Andrews, J.M.; Baillie, R.D.
    The enzymatic nature of human c1r: a subcomponent of the first component of complement (1979), J. Immunol., 123, 1403-1408.
    View publication on PubMed
Search for more literature for 3.4.21.41

Protein Variants

Protein Variants Comment Organism
R463X the mutations Arg463Gln, Arg463Lys or Arg463Phe all stabilize the zymogen state Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
diisopropyl fluorophosphate
-
 Homo sapiens
additional information above 0.0005 mM C1rbar the enzyme aggregates with loss of activity Homo sapiens
p-amidinophenylmethylsulfonyl fluoride
-
 Homo sapiens
p-tosyl-Lys-chloromethyl ketone
-
 Homo sapiens
phenylmethylsulfonyl fluoride
-
 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-acetyl-Arg methyl ester + H2O
-
 Homo sapiens N-acetyl-Arg + methanol
-
 ?
N-acetyl-Gly-Lys methyl ester + H2O
-
 Homo sapiens N-acetyl-Gly-Lys + methanol
-
 ?
N-carbobenzoxy-Lys-p-nitrophenyl ester + H2O
-
 Homo sapiens N-carbobenzoxy-Lys + 4-nitrophenyl
-
 ?
N-carbobenzoxy-Tyr-p-nitrophenyl ester + H2O
-
 Homo sapiens N-carbobenzoxy-Tyr + 4-nitrophenol
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
12.5
-
 N-Acetyl-Gly-Lys methyl ester
-
 Homo sapiens
18.3
-
 N-acetyl-Arg methyl ester
-
 Homo sapiens