Inhibitors | Comment | Organism | Structure |
---|---|---|---|
C1-inhibitor | regulates the classical and the lectin complement pathway inhibiting complement components C1r and C1s, and MASP-2, factor XIa, Factor XIIa, and plasma kallikrein, mechanism, overview | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | binding of four Ca2+ per enzyme dimer | Homo sapiens |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
88000 | - |
x * 88000, C1r zymogen, domain structure, overview | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C1s + H2O | Homo sapiens | the enzyme is part of the Ca2+-dependent tetramer C1s-C1r-C1r-C1s, termed as C1 complex, which is associated with the recognition molecule C1q, autoactivation of C1r, which then activates proenzyme C1s through cleavage at an Arg-Ile bond in the serine domain, C1r is active in the classical pathway of the complement system | activated complement component C1s + ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
glycoprotein | - |
Homo sapiens |
proteolytic modification | autoactivation of C1r as part of the C1 complex | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
complement component C1s + H2O | the enzyme is part of the Ca2+-dependent tetramer C1s-C1r-C1r-C1s, termed as C1 complex, which is associated with the recognition molecule C1q, autoactivation of C1r, which then activates proenzyme C1s through cleavage at an Arg-Ile bond in the serine domain, C1r is active in the classical pathway of the complement system | Homo sapiens | activated complement component C1s + ? | - |
? | |
complement component C1s + H2O | C1r cleaves proenzyme C1s at an Arg-Ile bond in the serine domain | Homo sapiens | activated complement component C1s + ? | - |
? |
Subunits | Comment | Organism |
---|---|---|
? | x * 88000, C1r zymogen, domain structure, overview | Homo sapiens |
More | C1 complex structure | Homo sapiens |
Synonyms | Comment | Organism |
---|---|---|
C1r | - |
Homo sapiens |