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Literature summary for 3.4.21.4 extracted from

  • Avanzo, P.; Sabotic, J.; Anzlovar, S.; Popovic, T.; Leonardi, A.; Pain, R.H.; Kos, J.; Brzin, J.
    Trypsin-specific inhibitors from the basidiomycete Clitocybe nebularis with regulatory and defensive functions (2009), Microbiology, 155, 3971-3981.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
clispin a Clitocybe nebularis trypsin inhibitor variant, recombinantly expressed in Escherichia coli, highly specific towards trypsin, fast-acting, and tight-binding. Molecular cloning of the gene and cDNA encoding cnispin, overview Homo sapiens
Clitocybe nebularis trypsin inhibitor CnSPI, several inhibitor variants, separation by trypsin affinity chromatography. Possible regulatory role for CnSPIs in the endogenous proteolytic system of Clitocybe nebularis. Isolation from frozen fruiting bodies or basidiocarps Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
lymphocyte peripheral blood Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
N-benzoyl-DL-arginine 4-nitroanilide + H2O
-
Homo sapiens N-benzoyl-DL-arginine + 4-nitroaniline
-
?
N-benzyloxycarbonyl-Phe-Arg-7-amido-4-methylcoumarin + H2O
-
Homo sapiens N-benzyloxycarbonyl-Phe-Arg + 7-amino-4-methylcoumarin
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
assay at Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Homo sapiens

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
additional information
-
additional information pseudo-first-order inhibition kinetics for trypsin, overview Homo sapiens
0.0000031
-
clispin pH 8.0, 37°C Homo sapiens