Literature summary for 3.4.21.4 extracted from

Sienczyk, M.; Oleksyszyn, J.
Inhibition of trypsin and urokinase by Cbz-amino(4-guanidinophenyl)methanephosphonate aromatic ester derivatives: the influence of the ester group on their biological activity (2006), Bioorg. Med. Chem. Lett., 16, 2886-2890.

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Inhibitors

Inhibitors	Comment	Organism	Structure
benzyloxycarbonyl-amino(4-guanidinophenyl)methyl-bis(4-ethylphenyl)phosphonate	50% inhibition at 0.000017 mM, comparison with inhibitory effect on urokinase	Bos taurus
benzyloxycarbonyl-amino(4-guanidinophenyl)methyl-bis(4-isopropylphenyl)phosphonate	50% inhibition at 0.000061 mM, comparison with inhibitory effect on urokinase	Bos taurus
benzyloxycarbonyl-amino(4-guanidinophenyl)methyl-bis(4-methylthiophenyl)phosphonate	50% inhibition at 0.0000087 mM, comparison with inhibitory effect on urokinase	Bos taurus
benzyloxycarbonyl-amino(4-guanidinophenyl)methyl-bis(4-t-butylphenyl)phosphonate	50% inhibition at 0.000088 mM, comparison with inhibitory effect on urokinase	Bos taurus

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	-	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
pancreas	-	Bos taurus	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
benzoyl-L-Arg-4-nitroanilide + H2O	-	Bos taurus	benzoyl-L-Arg + 4-nitroaniline	-	?

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Release 2023.1 (January 2023)